Topic: Ritalin can help prevent methamphetamine-induced neurotoxicity
The studies reviewed above help us to understand how MPD has the ability to provide neuroprotection against METH-induced neurotoxicity and perhaps Parkinson’s disease through possible mechanisms involving direct interactions with the DAT and additional mechanisms involving indirect effects upon the VMAT-2. These mechanisms, summarized in Fig. (33), attenuate or prevent the abnormal accumulation of cytoplasmic DA and the resulting formation of potentially neurotoxic DA-associated reactive species. At present, it is difficult to quantify the amount that any individual mechanism contributes to MPD neuroprotection in vivo.